Hybridoma Hbf-719, Producing Monoclonal Antibody Specific For Mouse Ly49f

Abstract

This invention concerns a hybridoma producing a mouse IgG1/kappa monoclonal antibody specific for the mouse Ly49F receptor. Mouse Ly49F is a homodimeric protein expressed on the surface of approximately 10% of NK cells, and a small fraction of T cells. Of T cells that express Ly49 receptors (approximately 15% of CD8 T cells), Ly49F is expressed weakly to the Dd classical class I molecule. The structure of the receptor suggests it may exert an inhibitory function.

Applications

The antibody is useful for staining the T cells and/or the NK cells that express the mouse 4Ly49F receptor.
The antibody may block ligand binding.